Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems
Patent
1997-12-04
1999-08-17
Kamm, William E.
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Electrical therapeutic systems
A61N 136
Patent
active
059386886
ABSTRACT:
The present subject matter is directed to a method for treating a conscious. The method includes selecting a conscious patient having impaired cognitive function and applying electrical stimulation to at least a portion of the patient's intralaminar nuclei under conditions effective to relieve the patient's impaired cognitive function. A method for improving coordination of function across a patient's cortical regions is also described. The method includes applying electrical stimulation to two or more subdivisions of the patient's intralaminar nuclei. The two or more subdivisions of the patient's intralaminar nuclei modulate separate cortical regions. Using the methods of the present invention, patients suffering from impaired cognitive function can have at least a portion of the function restored, thus improving their quality of life and reducing societal costs.
REFERENCES:
patent: 5269303 (1993-12-01), Wernicke et al.
patent: 5611350 (1997-03-01), John
Hinman et al., "Depth Evoked Potential and Single Unit Correlates of Vertex Midlatency Auditory Evoked Responses," Brain Research, 264:57-67 (1983).
Mantyh, "Connections of Midbrain Periaqueductal Gray in the Monkey. I. Ascending Efferent Projections," Journal of Neurophysiology, 49:567-581 (1983).
Velasco et al., "Neglect Induced by Thalamotomy in Humans: A Quantitative Appraisal of the Sensory and Motor Deficits," Neurosurgery, 19:744-751 (1986).
Dossi et al., "Short-Lasting Nicotinic and Long-Lasting Muscarinic Depolarizing Responses of Thalamocortical Neurons to Stimulation of Mesopontine Cholinergic Nuclei," Journal of Neurophysiology, 65:393-406 (1991).
Katayama et al., "Characterization and Modification of Brain Activity with Deep Brain Stimulation in Patients in a Persistent Vegetative State: Pain-Related Late Positive Component of Cerebral Evoked Potential," Pace, 14:116-121 (1991).
Grunwerg et al., "Sensory Responses of Intralaminar Thalamic Neurons Activated By The Superior Colliculus," Experimental Brain Research, 88:541-550 (1992).
Gainotti, "The Role of Spontaneous Eye Movements in Orienting Attention and in Unilateral Neglect," pp. 107-113, in Robertson et al., eds., Unilateral Neglect: Clinical and Experimental Studies, Hove, United Kingdom:Lawrence Erlbaum Associates, Publishers (1993).
Velasco, "Effect of Chronic Electrical Stimulation of the Centromedian Thalamic Nuclei on Various Intractable Seizure Patterns: II. Psychological Performance and Background EEG Activity," Epilepsia, 34:1065-1073 (1993).
Posner, "Attention: The Mechanisms of Consciousness," Proc. Natl. Acad. Sci. USA, 91:7398-7403 (1994.
Bottini et al., "Modulation of Conscious Experience by Peripheral Sensory Stimuli," Nature, 376:778-781 (1995).
Shapalova et al., "Role of the Activation of the Intralaminar Nuclei of the Thalamus in Regulating the Participation of the Neostraital Cholinergic System in the Differentiation of Acoustic Signals in Dogs," Neuroscience and Behavorial Physiology, 25:504-507 (1995).
Tasker et al., "The Role of the Thalamus in Functional Neurosurgery," Functional Neurosurgery, 6:73-104 (1995).
Barth et al., "Thalamic Modulation of High-Frequency Oscillating Potentials in Auditory Cortex," Nature, 383:78-81 (1996).
Benabid et al., "Chronic Electrical Stimulation of the Ventralis Intermedius Nucleus of the Thalamus as a Treatment of Movement Disorders," J. Neurosurg., 84:203-214 (1996).
Kinomura et al., "Activation by Attention of the Human Reticular Formation and Thalamic Intralaminar Nuclei," Science, 271:512-515 (1996).
Rinaldi et al., Cognitive Effects of Left Medial Thalamic Stimulation in Two Patients with Deep Brain Electrodes for Relief of Chronic Pain, Society of Neuroscience, 22:356.5 (1996).
Steriade, "Awakening the Brain," Nature, 383: 24-25 (1996).
Berg, "Screening Tests in Clinical Neuropsychology," Chapter 10, pp. 331-363, in Horton et al., eds., The Neuropsychology Handbook, vol. 1, Foundations and Assessment, 2nd ed., New York:Springer Publishing Company (1997).
Velasco et al., "Electrocortical and Behavioral Responses Produced by Acute Electrical Stimulation of th Human Centromedian Thalamic Nucleus," Electroencephalography and Clinical Neurophysiology, 102:461-471 (1997).
Purpura et al., "The Thalamic Intralaminar Nuclei: A Role in Visual Awareness," The Neuroscientist, 3:8-15 (1997).
Vallar et al., "Modulation of the Neglect Syndrome by Sensory Stimulation," pp. 555-578, in Thier et al., eds., Parietal Lobe Contributions to Orientation in 3D Space, Heidelberg, Germany:Springer-Verlag (1997).
Cornell Research Foundation Inc.
Kamm William E.
LandOfFree
Deep brain stimulation method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Deep brain stimulation method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Deep brain stimulation method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-310493