Decyanation of pergolide intermediate

Details Decyanation of pergolide intermediate Decyanation of pergolide intermediate

1985-08-16

1988-11-01

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D45702

Patent

active

047821523

ABSTRACT:
The present invention provides a process for decyanating a pergolide intermediate with an alkali metal hydroxide in an alcoholic solvent having a boiling point greater than about 100.degree. C. at a temperature in the range of about 100.degree. C. to about 175.degree. C.

REFERENCES:
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patent: 4284775 (1981-08-01), Temme
Organic Synthesis Coll. vol. I, 2nd. Ed. Wiley, New York (1946).
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Nickon et al., J. Am. Chem. Soc. 74, 5566-5570 (1952).
Robinson, Can. J. Chem. 32, 901-905 (1954).
Astill et al., J. Am. Chem. Soc. 77, 4079-4084 (1955).
Rapoport et al., J. Am. Chem. Soc. 89, 1942-1947 (1967).
Donetti et al., Tetrahedron Letters No. 39, 3327-3328 (1969).

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