Decreasing the melanin content in mammalian skin and hair using

Details Decreasing the melanin content in mammalian skin and hair using Decreasing the melanin content in mammalian skin and hair using

1989-10-06

1992-06-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Bleach for live hair or skin

424163, 424401, 514844, 514880, 514415, 548441, A61K 700, A61K 7135, A61K 31405, C07D20910

Patent

active

051261251

ABSTRACT:
A method of decreasing the melanin content in mammalian skin and hair by administering to a mammal a composition comprising an effective amount of one or more derivatives of 5,6-dihydroxyindole, the derivatives having one or more substituents which are capable of being removed enzymatically, in admixture with a pharmaceutically acceptable carrier, the amount being 0.5% to 20% wt/wt based on the composition.

REFERENCES:
patent: 4595765 (1986-06-01), Murphy
patent: 4822375 (1989-04-01), Lang
patent: 4859668 (1989-08-01), Noga
J. M. Pawelek and A. B. Lerner, "5,6-Dihydroxyindole is a Melanin Precursor Showing Potent Cytotoxicity", Nature, 276, 627-628, (1978).
J. M. Pawelek and M. Murray, "Increase in Melamin Formation and Promotion of Cytotoxicity in Cultured Melanoma Cells Caused by Phosphorylated Isomers of L-Dopa", Cancer Research, 46, 493-497, (1986).
A. Korner, and J. Pawelek, "Mammalian Tyrosinase Catalyzes Three Reactions in the Biosynthesis of Melanin", Science, 217, 1163-1165, (1982).
J. Pawelek, A. Korner, A. Bergstrom and J. Bolognia, "New Regulators of Melanin Biosynthesis and the Autodestruction of Melanoma Cells", Nature, 286, 617-619, (1980).
J. M. Pawelek, "Factors Regulating Growth and Pigmentation of Melanoma Cells", J. Invest. Derm., 66, 201-209, (1976).
J. McLane, M. Osber and J. M. Pawelek, "Phosphorylated Isomers of L-Dopa Stimulate MSH Binding Capacity and Responsiveness to MSH in Cultured Melanoma Cells", BBRC, 145, 719-725.

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