Liquid purification or separation – With means to add treating material – Chromatography
Patent
1991-12-06
1993-08-31
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
210634, 210635, 210656, 210659, 210137, 210143, 203 49, 422255, 96103, B01D 1508
Patent
active
052406032
ABSTRACT:
Methods and apparatus for extracting sample components from complex matrices using supercritical fluid as the principal extracting solvent are disclosed. The invention takes advantage of the fact that the solvent power of a supercritical fluid is stepwise settable by the parameters of density, modifier concentration, and temperature. Accordingly, methods and apparatus for extracting a component from a sample using fluid flow system having a variable and controllable flow restriction are disclosed. The methods of the present invention comprise the steps of inserting the sample into the sample container section, inputting temperature, pressure, flow rate and extraction time set points. Flow rate is controlled and system pressure regulated by the variable flow restriction. The output stream from the extraction is then expanded through a nozzle and into a trap. In certain embodiments, the trap is filled with chemically active packing material. In other embodiments, a fractionation zone and other analytical instruments are coupled to the apparatus of the present invention. Methods and apparatus for rinsing the extraction instrument and for diluting the extraction fluid are also disclosed. Methods for operating a supercritical fluid extraction systems comprising a pressure and thermal control systems which are programmable to regulate the system to maintain such values within the design specifications during the extraction process are also disclosed.
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Abstract of Japan Pat. No. 60291155, Patent Abstracts of Japan, vol. 011-378, Dec. 24, 1985, p. 1.
Dryden Paul C.
Engel Steven J.
Frank Lenore R.
Nickerson Mark A.
Wurm Christopher M.
Hewlett--Packard Company
Schuette Richard F.
Therkorn Ernest G.
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