Decorin proteoglycan inhibitor of fibrinogen blood clotting

Details Decorin proteoglycan inhibitor of fibrinogen blood clotting Decorin proteoglycan inhibitor of fibrinogen blood clotting

2006-08-22

2006-08-22

Carlson, Karen Cochrane (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

07094880

ABSTRACT:
The present invention provides compositions and methods of inhibiting fibrin(ogen) clot formation by utilizing decorin proteoglycan as an anticoagulating and antithrombotic agent. The decorin proteoglycan comprises a decorin core protein or a fragment thereof covalently linked to a galactosaminoglycan polysaccharide. The decorin core protein acts as an anticoagulant and as a carrier for the delivery of an antithrombotic galactosaminoglycan to fibrinogen. Fibrin clotting is inhibited by the decorin proteoglycan in a concentration-dependent fashion.

REFERENCES:
patent: 2003/0148351 (2003-08-01), Henry et al.
Seidler et al., Core protein dependence of epimerization of glucuronosyl residues in galactosaminoglycans, J. Biol. Chem., (2002), 277(44), p. 42409-42416.
Oldberg et al., Amino terminal deletions in the decorin core protein leads to the biosynthesis of proteoglycans with shorter glycosaminoglycan chains, FEBS Letters, (1996), 386, p. 29-32.
Hauser et al., Different galactosaminoglycan composition of small proteoglycans from osteosarcoma cells, Glycobiology, (1993), 3(6), p. 557-562.

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