Decorin fragments inhibiting cell regulatory factors

Details Decorin fragments inhibiting cell regulatory factors Decorin fragments inhibiting cell regulatory factors

1995-05-16

1998-01-06

Jagannathan, Vasu S.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530324, 530399, 930 10, 514 17, C07K 706, C07K 14435, A61K 3808, A61K 3817

Patent

active

057056099

ABSTRACT:
The present invention provides a method of inhibiting an activity of a cell regulatory factor comprising contacting the cell regulatory factor with a purified polypeptide, wherein the polypeptide comprises a cell regulatory factor binding domain of a protein. The protein is characterized by a leucine-rich repeat of about 24 amino acids. In a specific embodiment, the present invention relates to the ability of decorin, a 40,000 dalton protein that usually carries a glycosaminoglycan chain, and more specifically to active fragments of decorin or its functional equivalents to bind TGF.beta.. The invention also provides a novel cell regulatory factor designated MRF. Also provided are methods of identifying, detecting and purifying cell regulatory factors and proteins which bind and affect the activity of cell regulatory factors.

REFERENCES:
patent: 5171674 (1992-12-01), Stevens et al.
patent: 5229495 (1993-07-01), Ichijo et al.
Krusius et al Proc Natl Acad Sci 83: 7683-7688 (1986).
Ruoslahti Ann Rev Cell Biol 4: 229-55 (1988).
Kahari et al. J of Biol Chem 266(16):10608-15 (1991).
Yamaguchi et al Nature 346: 281-284 (1990).
Krusius et al. Biochem. 83: 7683-7687, 1986.
Fisher et al. J. Biol. Chem. 264(8): 4571-4576, 1989.
Cheifetz et al. J. Biol. Chem. 263(22):10783-10789, 1988.
Cheifetz et al. J. Biol. Chem. 263(32):16984-16991, 1988.
Pearson et al. J. Biol. Chem. 258(24):15101-15104, 1983.
Fritze et al. J. Biol. Chem. 100:1041-1049, 1985.
Castellot et al. Am. J. Pathol. 125:493-500, 1986.
Castellot et al. J. Biol. Chem. 257(19):11256-11260, 1982.
Vogel et al. Biochem J. 223:587-597, 1984.
Massague et al. J. Biol. Chem 260(5):2636-2645, 1985.
Andres et al. J. Cell Biol. 109(6): 3137-3145, 1989.
Kanzaki et al. Cell 61: 1051-1061, 1990.
Brennan et al. Can. Res. 43: 4302-4307, 1983.
Brennan et al. J. Biol. Chem 258(22): 13742-13750, 1984.
Kresse et al. Am. J. Hum. Genet. 41, 1987.
Yamaguchi et al. Nature 336: 244-246, 1983.
Patthy, L. J. Mol. Biol. 198: 567-577, 1987.
Bassols et al. J. Biol Chem. 263(6):3039-3045, 1988.
Segarini et al. J. Biol. Chem. 263(17): 8366-8370, 1988.
Cheifetz et al. Cell: 409-415, 1987.
Ishihara et al. J. Biol. Chem. 262(10): 4708-4716, 1987.
Day et al. Biochem J. 248:801-805, 1987.

Affiliated with

Also associated with

Rating

Decorin fragments inhibiting cell regulatory factors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Decorin fragments inhibiting cell regulatory factors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Decorin fragments inhibiting cell regulatory factors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2329938