Decorin binding protein compositions and methods of use

Details Decorin binding protein compositions and methods of use Decorin binding protein compositions and methods of use

1996-01-22

1998-12-29

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 221, 536 231, 536 237, 536 2433, 536 2532, 4353201, 435 912, 435 6, 530350, C07H 2104, C07H 2102, C12P 1934, C12Q 168

Patent

active

058539875

ABSTRACT:
Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding protein compositions and methods of use. The DBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological Borrelia infections, and in particular, for use in the prevention of bacterial adhesion to decorin. DNA segments encoding these proteins and anti-(decorin binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of Borrelia colonization in an animal. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of Lyme disease.

REFERENCES:
Genovese et al., Construction of DNA Sequence Complementary to Rat alpha-1 and alpha-2 Collagen mRNA and Their Use in Studying the Regulation of Type I Collagen Synthesis by 1,25-Dihydroxyvitamin D, Biochemistry, vol. 23, No. 24, pp. 6210-6216, 1984.
Oldberg et al., A Collagen-Binding 59-kd Protein (fibromodulin) is Structurally Related to the Small Interestitial Proteoglycans PG-S1 and PG-S2 (decorin), 1989, vol. 8, No. 9, pp. 2601-2604.

Affiliated with

Also associated with

Rating

Decorin binding protein compositions and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Decorin binding protein compositions and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Decorin binding protein compositions and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1423299