Deconvolving chromatographic peaks

Details Deconvolving chromatographic peaks Deconvolving chromatographic peaks

1987-05-29

1989-02-21

Lall, Parshotam S.

Boots, shoes, and leggings

364497, 364577, 73 231, 73 611C, G01N 3108

Patent

active

048071480

ABSTRACT:
Deconvolution of up to three overlapping chromatographic peaks is provided in which pure spectral components are extrapolated from a Euclidean-normalized expression of chromatographic data in the space of the three principal factors. A coordinate transformation to planar coordinates after expansion in factor space and before extrapolation yields the simplicity of linear extrapolation in combination with the inherent accuracy of Euclidean, as opposed to standard, normalization. The estimation of the pure component spectra permits the constructions of a concentration matrix. Improved estimates and an error bound are provided by applying assumptions of non-negativity and limited deviation from the means to the concentration matrix.

REFERENCES:
patent: 4180857 (1979-12-01), Yoshihara et al.
patent: 4314343 (1982-02-01), Tomlinson
patent: 4353242 (1982-10-01), Harris et al.
patent: 4374424 (1983-02-01), Coustre et al.
patent: 4642778 (1987-02-01), Hieftje et al.

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