Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-03-22
2011-03-22
Peselev, Elli (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S007200, C536S007400
Reexamination Certificate
active
07910559
ABSTRACT:
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
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Tanikawa et al., “Synthesis and Antibacterial Activity of Acylides (3-0-Acyl-Erythromycin Derivatives): A Novel Class of Macrolide Antibiotics,” Journal of Medicinal Chemistry, V44 N24, 2001, pp. 4027-4030.
Alihodzic Sulejman
Bosnar Martina
Culic Ognjen
Hutinec Antun
Istuk Zorica Marusic
GlaxoSmithKline Istrazivacki Centar Zagreb D.O.O.
Peselev Elli
Prus Karen L.
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