Dechloromaytansinoids, their pharmaceutical compositions and met

Details Dechloromaytansinoids, their pharmaceutical compositions and met Dechloromaytansinoids, their pharmaceutical compositions and met

1979-11-09

1981-03-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393P, C07D49806, A61K 31535

Patent

active

042567467

ABSTRACT:
Novel dechloromaytansinoids of the formula: ##STR1## wherein R is H or acyl having 1 to 20 carbon atoms, have antimitotic, antitumor and antimicrobial activities.

REFERENCES:
patent: 3896111 (1975-07-01), Kupchan et al.
patent: 4137230 (1979-01-01), Hashimoto et al.
patent: 4162940 (1979-07-01), Higashide et al.
Kupchan et al., "J. Med. Chem.", (1978), vol. 21, No. 1, pp. 31-37.
March, "Advanced Organic Chemistry", (McGraw-Hill), pp. 439-440 (1968).

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