Decapeptides produced from bioadhesive polyphenolic proteins

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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435 69, C07C10352, C12P 2106

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active

045855854

ABSTRACT:
Methods are described for the preparation and isolation of novel decapeptides of the formula: ##STR1## wherein each X is independently selected from the group comprising hydroxyl and hydrogen, wherein each R is independently selected from the group comprising hydrogen and methyl, from bioadhesive polyphenolic proteins which comprise: ##STR2## wherein n is a whole number from about 60 to about 100, wherein each X is independently selected from the group comprising hydroxyl and hydrogen, and wherein each R is independently selected from the group comprising hydrogen and methyl.
Such decapeptides may be used to construct large polyphenolic molecules comprising from about 1 to about 1000 decapeptide repeating units and wherein the linking group is selected from the group comprising amino acid, oligopeptide and bifunctional spacer.

REFERENCES:
patent: 4302386 (1981-11-01), Stevens
The Journal of Biological Chemistry, vol. 258, No. 5, Issue of Mar. 10, 1983, 2911-2915.

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