Debrominative chlorination of pyrroles

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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548562, C07D20734

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active

055632793

ABSTRACT:
There is provided a simple quantitative procedure for the chlorination of pyrrole compounds containing electron withdrawing substituents via the displacement of bromine with chlorine on the pyrrole nucleus.

REFERENCES:
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patent: 5010098 (1991-04-01), Brown et al.
patent: 5162308 (1992-11-01), Brown et al.
patent: 5449789 (1995-09-01), Kameswaran
Mar., "Advanced Organic Chemistry-Reactions, Mechanisms, & Structure". 4ed. John Wiley & Sons (1992) pp. 649-651, 659.
J. Savir, R. Huisgen. "Nucleophile Aromatisehe Substitutioner mit addtivem Chemismus." Angew Chem, (72), Jan. 1960 pp. 294, 298.
J. Bunnett, R. Zahler. "Aromatic Nucleophilic Substitution Reactions." Chemical Reviews, vol. 49 pp. 273, 277. Mar. 1951.

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