Death domain containing receptors

Details Death domain containing receptors Death domain containing receptors

2008-04-15

2008-04-15

O'Hara, Eileen B. (Department: 1646)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S133100, C424S139100, C424S141100, C424S143100, C530S387100, C530S387300, C530S387900, C530S388100, C530S391100, C530S391300, C530S389100, C530S388220, C530S350000, C435S326000, C435S331000, C435S334000

Reexamination Certificate

active

10189189

ABSTRACT:
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

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