Dealkylation of opioid ethers

Details Dealkylation of opioid ethers Dealkylation of opioid ethers

1985-06-06

1987-05-19

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 45, 546 46, 546 74, 568805, C07D48902, C07D48906, C07C 37055

Patent

active

046670378

ABSTRACT:
An improved process for the dealkylation of alkyl aryl ethers to aryl phenols is provided. In this process, an alkyl aryl ether, such as a methyl ether of an opioid, is contacted with an aqueous acid selected from HBr, HCl, or HI which contains at least one equivalent weight, based on the ether, of boric acid or an inorganic salt of a metal selected from Li, Na, K, Al, Mg, Ca, Mn and Ni. MgBr.sub.2 in aqueous HBr is preferred in dealkylating an N-substituted 14-hydroxydihydronorcodeine.

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patent: 4351968 (1982-09-01), Harris
M. V. Bhatt and S. U. Kulkarni, Synthesis, 249 282 (1983).

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