DEAH-box proteins

Details DEAH-box proteins DEAH-box proteins

1996-12-04

1999-08-24

Wax, Robert A

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435199, 43525233, 435325, 4353201, 536 231, 536 232, 536 235, C12N 916, C07H 2104

Patent

active

059424290

ABSTRACT:
The present invention relates to the identification and molecular-biological and biochemical characterization of novel DEAH-box proteins which show structural similarity with other known helicases. The invention also relates to DNA sequences encoding such proteins. It is demonstrated that such proteins bind ATP and nucleic acid and possess helicase and ATPase activities. This invention further relates to processes for preparation of such proteins and their use in pharmacologically relevant test systems and therapeutic applications.

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