Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-10-28
1999-11-23
Railey, II, Johnny F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 232, 536 237, C12N 1531, C12N 121, C12N 1563, C07K 1431
Patent
active
059898585
ABSTRACT:
The invention provides dbpB polypeptides and DNA (RNA) encoding dbpB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dbpB polypeptides to screen for antibacterial compounds.
REFERENCES:
Lane, D.P., GenBank Submission, Accession No. X52647, Direct Submission.
Iggo, et. al., "Identification of a putative RNA heliocase in E. Coli." Nucleic Acids Research, vol. 18, No. 18, pp. 5413-5417, (1990).
Boddeker, et. al., "Charactarization of DbpA, an Escherichia coli DEAD box protein with ATP independent RNA unwinding activity." Nucleic Acids Research, vol. 25, No. 3, pp. 537-544, (1997).
Nicol, et. al., "The "DEAD box" protein DbpA interacts specifically with the peptidyltransferase center in 23S rRNA." Pro. Natl. Acad. Sci. U.S.A., Biochemistry, vol. 92, pp. 11681-11685, Dec. (1995).
Fuller-Pace, et. al., "DdpA: a DEAD box protein specifically activated by 23S RNA." The EMBO Journal, vol. 12, No. 9, pp. 3619-3626, (1993).
Huang Jianzhong
McDevitt Damien
Traini Christopher M
Wang Min
Deibert Thomas S.
Gimmi Edward R.
King William T.
Railey II Johnny F.
SmithKline Beecham Corporation
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