Deacylative bromination process for the preparation of molluscic

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07B 3900, C07D20734

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active

050084038

ABSTRACT:
There is provided a method of preparation of 2,4,5-tribromopyrrole-3-carbonitrile compounds in a single deacylative bromination step from their 2-trihaloacetylpyrrole-4-carbonitrile precursors. The 2,4,5-tribromopyrrole-3-carbonitrile compounds are useful as molluscicidal agents.

REFERENCES:
Merck Index, 11th Edition, p. 1268.
1990-1991 Aldrich catalogue.
Fieser & Fieser, Reagents for Organic Synthesis, vol. 1, p. 967 (1987).
Katritzky, "Comprehensive Heterocyclic Chemistry", vol. 4, p. 215 (1983).
A. M. van Leusen et al., Tetrahedron Letters, 5337 (1972).
C. E. Loader et al., Canadian Journal of Chemistry, 59, 2673 (1981).
H. J. Anderson et al., Synthetic Communications, 17, 401 (1987).
P. E. Sonnett, Journal of Medicinal Chemistry, 1972, 15, pp. 97-98.

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