Deacylation of LPS in gram negative bacteria

Details Deacylation of LPS in gram negative bacteria Deacylation of LPS in gram negative bacteria

2005-12-16

2011-11-01

Ogunbiyi, Oluwatosin (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S249100, C424S250100, C424S253100, C424S254100, C424S093100, C424S093200, C435S320100, C435S252100, C435S252300, C536S023100, C536S023200, C536S023700

Reexamination Certificate

active

08048433

ABSTRACT:
The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such asBordetella pertussis, Bordetella parapertussisandBordetella bronchiseptica.

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