Deacetylcolchicine derivatives

Details Deacetylcolchicine derivatives Deacetylcolchicine derivatives

1991-12-20

1993-06-15

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514629, 514630, 514676, A61K 3170, A61K 4748, C07H 700, C07C23514

Patent

active

052200027

ABSTRACT:
Deacetylcolchicine derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C.sub.3 -C.sub.7 sugar carboxylic acid, and a hydroxyl group present in the residue may properly be protected with a protecting group of the hydroxyl group.
Said deacetylcolchicine derivatives have less toxicity and strong effect for inhibiting proliferation of tumor cells, and are expected to be used as an antitumor agent.

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Raffauf et al., J. Am. Chem. Soc., vol. 75, pp. 5292-5294 (1953).
Ueno, J. Pharm. Soc. Japan, vol. 73, pp. 1238-1242 (1953).
Shiau et al., J. Pharm. Sci., vol. 67, No. 3, pp. 394-397 (1978).
Clark et al., Life Sciences, vol. 26, pp. 833-836 (1980).
Iorio et al., Can. J. Chem., vol. 59 (1981) pp. 283-284 (1981).

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