Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Patent
1994-01-07
1995-11-14
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
435193, 435 49, 4353201, 4352564, 536 232, C12N 114, C12N 910, C12N 1554, C12P 3506
Patent
active
054665981
ABSTRACT:
A DNA is disclosed, which comprises a gene coding for deacetylcephalosporin C acetyltransferase, i.e., an enzyme capable of catalyzing the final step of the biosynthesis of cephalosporin C. The gene may be either a cDNA or a genomic DNA. Also disclosed is a recombinant DNA comprising a vector having inserted therein at least a portion of the above-mentioned DNA, which recombinant DNA is in a form such that the portion is capable of expression in Acremonium chrysogenum. Acremonium chrysogenum transformed with the recombinant DNA can be advantageously used for efficiently preparing cephalosporin C.
REFERENCES:
Scheidegger et al., Journal of Biotechnology, 3 (1985) 109-117.
Skatrud et al., Biotechnology, pp. 477-485, vol. 7 (1989).
Fujisawa et al., Agr. Biol. Chem. 39, 2043-2048 (1975).
Matsuda et al. (1992) Biochem Biophys Res. Comm. 182, 995-1001.
Samson et al. (1985) Nature 318, 191-194.
Davis et al. (1986) in "Basic Methods in Molecular Biology" Elsevier, New York, pp. 194-218.
Matsuda Akio
Matsuyama Kenji
Asahi Kasei Kogyo Kabushiki Kaisha
Hendricks Keith D.
Wax Robert A.
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