Deacetylase inhibitors

Details Deacetylase inhibitors Deacetylase inhibitors

2006-06-27

2006-06-27

Lambkin, Deborah C. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S496000, C514S575000, C562S621000, C549S441000, C548S495000

Reexamination Certificate

active

07067551

ABSTRACT:
The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

REFERENCES:
patent: 5534654 (1996-07-01), Ohtani et al.
patent: 5569668 (1996-10-01), Webster et al.
patent: 5722242 (1998-03-01), Edelson
patent: 6127392 (2000-10-01), Lennox et al.
patent: 6541661 (2003-04-01), Delorme et al.
patent: 6552065 (2003-04-01), Remiszewski et al.
patent: 6706686 (2004-03-01), Long et al.
patent: 2002/0061860 (2002-05-01), Li et al.
patent: 2004/0029928 (2004-02-01), Hirata et al.
patent: 10182583 (1998-07-01), None
patent: 95/31977 (1995-11-01), None
patent: 97/35990 (1997-10-01), None
patent: 98/55449 (1998-12-01), None
patent: 99/07669 (1999-02-01), None
patent: 00/23112 (2000-04-01), None
patent: 00/39081 (2000-07-01), None
patent: 00/59880 (2000-10-01), None
patent: 01/18171 (2001-03-01), None
patent: 01/21595 (2001-03-01), None
patent: 01/38322 (2001-05-01), None
patent: 01/42437 (2001-06-01), None
patent: 01/70675 (2001-09-01), None
patent: 02/22577 (2002-03-01), None
patent: 02/28835 (2002-04-01), None
patent: 02/085400 (2002-10-01), None
patent: 02/085844 (2002-10-01), None
patent: 03/006652 (2003-01-01), None
patent: 03/016270 (2003-02-01), None
Giliane Bouchain et al., “Development of Potential Antitumor Agents, Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors,” J. Med. Chem., vol. 46, pp. 820-830 (2003).
Jack Taunton et al., “Synthesis of Natural and Modified Trapoxins, Useful Reagents for Exploring Histone Deacetylase Function,” J. Am. Chem. Soc. 1996, vol. 118, pp. 104112-10422 (1996).
Joseph J. Buggy et al., “Cloning and characterization of a novel human histone deacetylase, HDAC8,” Biochem J., vol. 350, pp. 199-205 (2000).
Marielle Fournel et al., “Sulfonamide Anilides, a Novel Class of Histone Deacetylase Inhibitors, Are Antiproliferative against Human Tumors,” Cancer Research, vol. 62, pp. 4325-4330 (2002).
Minoru Yoshida et al., “Histone deacetylase as a new target for cancer chemotherapy,” Cancer Chemother. Pharmacol., vol. 48 (Suppl. 1); pp. S20-S26 (2001).
Rico Lavoie et al., “Design and Synthesis of a Novel Class of Histone Decacetylase Inhibitors,” Bioorganic & Medicinal Chemistry Letters 11, pp. 2847-2850 (2001).
Soon Hyung Woo et al., “Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors,” J. Med. Chem., vol. 45, pp. 2877-2885 (2002).
Young Bae Kim et al., “Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase,” Oncogene, vol. 18, pp. 2461-2470 (1999).
Streitwieser et al., Introduction to Organic Chemistry, 2ndEdition, Chapt. 11, p. 282.

Affiliated with

Also associated with

Rating

Deacetylase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Deacetylase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Deacetylase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3649749