Deacetoxycephalosporins via penicillin sulfoxide rearrangement

Details Deacetoxycephalosporins via penicillin sulfoxide rearrangement Deacetoxycephalosporins via penicillin sulfoxide rearrangement

1974-12-13

1976-04-27

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50110

Patent

active

039534405

ABSTRACT:
Penicillin sulfoxides, notably the sulfoxides of penicillin V and penicillin G, are heated with amine salts of dichloromethane phosphonate in 1,1,2-trichloroethane to provide superior yields of deacetoxycephalosporins. The process is especially valuable in providing greater yields of the intermediate in the synthesis of the commercial antibiotic, cephalexin.

REFERENCES:
patent: 3725397 (1973-04-01), Graham et al.
patent: 3725399 (1973-04-01), Ellerton et al.
patent: 3819622 (1974-06-01), Cowley et al.
patent: 3843637 (1974-10-01), Rubinfeld et al.

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