De-novo sequencing of nucleic acids

Details De-novo sequencing of nucleic acids De-novo sequencing of nucleic acids

2011-02-15

2011-02-15

Brusca, John S (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C250S283000

Reexamination Certificate

active

07890268

ABSTRACT:
The present invention is directed to an improved analysis procedure for the comparative sequencing of nucleic acids using multistage mass spectrometry. More precisely, the invention is directed to a method enabling the de-novo sequencing of nucleic acid molecules using multistage mass spectrometry.

REFERENCES:
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patent: 6051378 (2000-04-01), Monforte et al.
Oberacher et al. Automated De Novo Sequencing of Nucleic Acids by Liquid Chromatography-Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry vol. 15, pp. 32-42 (2003).
Oberacher et al. Comparative Sequencing of Nucleic Acids by Liquid Chromatography-Tandem Mass Spectrometry. Analytical Chemistry vol. 74 pp. 211-218 (2002).
Fogel An introduction to Simulated Evolutionary Optimization. IEEE Transactions on Neural Networks vol. 5, pp. 3-14 (1994).
Keith et al. A simulated annealing algorithm for finding consensus sequences. Bioinformatics vol. 18 pp. 1494-1499 (2002).
Oberacher et al. Re-sequencing of multiple single nucleotide polymorphisms by liquid chromatography-electrospray ionization mass spectrometry Nucleic Acids Research vol. 30 p. e67 (2002).
Stepniewski, Slawomir W., et al., 1997, “Pruning Backpropogation Neural Networks Using Modern Stochastic Optimisation Techniques”, Neural Comput & Applic, 5:76-98.

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