Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-03-11
2008-03-11
Harris, Alana M. (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S001001, C536S018700, C536S022100, C536S023100, C536S023500, C530S300000, C530S350000, C435S004000, C435S006120, C435S007210, C435S069100, C435S069200, C435S183000, C435S325000
Reexamination Certificate
active
09720086
ABSTRACT:
De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, for an in vitro DNA methylation application and therapeutic applications such as the treatment of neoplastic disorders.
REFERENCES:
patent: 5578716 (1996-11-01), Szyf et al.
patent: 6183968 (2001-02-01), Bandman et al.
patent: 6492168 (2002-12-01), Kladde et al.
patent: WO 92/06985 (1992-04-01), None
patent: WO9514772 (1995-06-01), None
GenCore nucleic acid and amino acid database. Sequence comparison between accession No. AF067972 from Gene 1999 paper and Applicants' SEQ ID No. 7 and 8, Feb. 12, 2001.
Okano et al. Cloning and characterizationof a family of novel mammalian DNA (cytosine-5) methyltransferases. Nature Genetics 19:219 and 220, Jul. 1998.
GenCore nucleic acid database. Sequence comparison between accession No. AAT21884 from WO document 9514772-A1 and Applicants' SEQ ID No. 1 and 3, Jun. 1, 1995.
GenCore nucleic acid and amino acid database. Sequence comparison between sequence 47 of U.S. Patent 6,183,968 and Applicants' SEQ ID No. 2 and 5-8, Mar. 27, 1998.
Lazar et al. Transforming Grouwth Factor alpha: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities. Molecular and Cellular Biology 8(3): 1247-1252, Mar. 1998.
Editors, Ausubel et al. Current Protocols in Molecular Biology, Supplement 10, vol. 2:16.8.1-16.11.7, 1990.
Xie et al. Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236(1): 87-95, 1999.
GenCore nucleic acid and amino acid database. Sequence comparison between accession No. AF069625 from nature Genetics 1998 paper and Applicants' SEQ ID No. 5 and 6, Dec. 6, 1999.
GenCore database. Sequence alignment between SEQ ID No. 3 and Accession No. AF067972 of Xie et al. Gene 236(1): 87-95, 1999, 3 sheets.
GenCore database. Sequence alignment between SEQ ID No. 2 and Accession No. AF068626 and AF068627 of Okano et al. Nat. Genet. 19(3): 219 and 220, 1998, 8 sheets.
GenCore DNA sequence alignment between prior art and Applicants' SEQ ID No. 1-4, a total of 18 sheets.
Okano, M., et al., “Dnmt2 is not required forde novoand maintenance methylation of viral DNA in embryonic stem cells,”Nucl. Acids Res. 26:2536-2540, Oxford University Press (Jun. 1998).
Pradhan, S., et al., “Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase,”Nucl. Acids Res. 25:4666-4673, Oxford University Press (Nov. 1997).
Aoki, A., et al., “Enzymatic properties ofde novo-type mouse DNA (cytosine-5) methyltransferases,”Nucl. Acids Res. 29:3506-3512, Oxford University Press (Sep. 2001).
Ariel, M., et al., “Gamete-specific methylation correlates with imprinting of the murine Xist gene,”Nat. Genet. 9:312-315, Nature Publishing Group (1995).
Bachman, K.E., et al., “Dnmt3a and Dnmt3b Are Transcriptional Repressors That Exhibit Unique Localization Properties to Heterochromatin,”J. Biol. Chem. 276:32282-32287, The American Society for Biochemistry and Molecular Biology, Inc. (Aug. 2001).
International Search Report for International Application No. PCT/US99/14373, mailed Dec. 10, 1999, European Patent Office, Netherlands.
Baylin, S.B., et al., “Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia,”Adv. Cancer Res. 72:141-196, Academic Press (Feb. 1998).
Bestor, T., et al., “Cloning and Sequencing of a cDNA Encoding DNA Methyltransferase of Mouse Cells,”J. Mol. Biol. 203:971-983, Academic Press (1988).
Bestor, T.H., “Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain,”EMBO J. 11:2611-2617, Oxford University Press (1992).
Brandeis, M., et al., “The ontogeny of allele-specific methylation associated with imprinted genes in the mouse,”EMBO J.12:3669-3677, Oxford University Press (1993).
Brockdorff, N., “Convergent themes in X chromosome inactivation and autosomal imprinting,” inGenomic Imrinting, Reik, W., and Surani, A., eds., Oxford University Press, Oxford, UK, pp. 191-210 (Dec. 1997).
Chaillet, J.R., et al., “Parental-Specific Methylation of an Imprinted Transgene in Established during Gametogenesis and Progressively Changes during Embryogenesis,”Cell 66:77-83, Cell Press (1991).
Chen, T., et al., “A Novel Dnmt3a Isoform Produced from an Alternative Promoter Localizes to Euchromatin and Its Expression Correlates with Activede NovoMethylation,”J. Biol. Chem. 277:38746-38754, The American Society for Biochemistry and Molecular Biology, Inc. (Oct. 2002).
Cheng, X., “Structure and function of DNA methyltransferases,”Annu. Rev. Biophys. Biomol. Struct. 24:293-318, Annual Reviews, Inc. (1995).
Finnegan, E.J., and Dennis, E.S., “Isolation and identification by sequence homology of a putative cytosine methyltransferase fromArabidopsis thaliana,” Nucl. Acids Res. 21:2383-2388, Oxford University Press (1993).
Flynn, J., et al., “Murine DNA Cytosine-C5Methyltransferase: Pre-Steady- and Steady-State Kinetic Analysis with Regulatory DNA Sequences,”Biochem. 35:7308-7315, American Chemical Society (1996).
Flynn, J., et al., “DNA Binding Discrimination of the Murine DNA Cytosine-C5Methyltransferase,”J. Mol. Biol. 279:101-116, Academic Press (May 1998).
Hata, K., et al., “Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice,”Develop. 129:1983-1993, Company of Biologists Ltd. (Apr. 2002).
Jähner, D., and Jaenisch, R., “DNA Methylation in Early Mammalian Development,” inDNA Methylation. Biochemistry and Biological Significance, Razin, A., eds., Springer-Verlag, New York, NY, pp. 189-219 (1984).
Jentsch, S., et al., “DNA methyltransferases affecting the sequence 5′CCGG,”Nucl. Acids Res. 9:2753-2759, IRL Press (1981).
Jones, P.A., and Gonzalgo, M.L., “Altered DNA methylation and genome instability: A new pathway to cancer?,”Proc. Natl. Acad. Sci. USA 94:2103-2105, National Academy of Sciences (Mar. 1997).
Klima{hacek over (s)}auskas, S., et al., “The sequence specificity domain of cytosine-C5 methylases,”Nucl. Acids Res. 19:6183-6190, IRL Press at Oxford University Press (1991).
Kumar, S., et al., “The DNA (cytosine-5) methyltransferases,”Nucl. Acids Res. 22:1-10, Oxford University Press (1994).
Laird, P.W., and Jaenisch, R., “The Role of DNA Methylation in Cancer Genetics and Epigenetics,”Annu. Rev. Genet. 30:441-464, Annual Reviews Inc. (1996).
Lauster, R., et al., “Cytosine-specific Type II DNA Methyltransferases. A Conserved Enzyme Core with Variable Target-recognizing Domains,”J. Mol. Biol. 206:305-312, Academic Press Ltd. (1989).
Lei, H., et al., “De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells,”Development 122:3195-3205, The Company of Biologists Ltd. (1996).
Leonhardt, H., et al., “A Targeting Sequence Directs DNA Methyltransferase to Sites of DNA Replication in Mammalian Nuclei,”Cell 71:865-873, Cell Press (1992).
Li, E., et al., “Targeted Mutation of the DNA Methyltransferase Gene Results in Embryonic Lethality,”Cell 69:915-926, Cell Press (1992).
Li, E., “Role of DNA methylation in mammalian development,” inGenomic Imprinting, Reik, W., and Surani, A. eds., Oxford University Press, Oxford, UK, pp. 1-20 (Dec. 1997).
Malagnac, F., et al., “A Gene Essential for De Novo Methylation and Development in Ascobolus Reveals a Novel Type of Eukaryotic DNA Methyltransferase Structure,”Cell 91:281-290, Cell Press (Oct. 1997).
Narayan, A., et al., “Hypomethylation of Pericentromeric DNA in Breast Adenocarcinomas,”Int. J. Cancer 77:833-838, Wiley-Liss, Inc. (Sep. 1998).
Okano, M., et al
Li En
Okano Masaki
Xie Shaoping
Harris Alana M.
Sterne Kessler Goldstein & Fox P.L.L.C.
The General Hospital Corporation
LandOfFree
De novo DNA cytosine methyltransferase genes, polypeptides... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with De novo DNA cytosine methyltransferase genes, polypeptides..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and De novo DNA cytosine methyltransferase genes, polypeptides... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3947268