Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-09-06
2008-12-16
Blanchard, David J. (Department: 1643)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C424S094100, C435S069100, C435S183000, C530S350000
Reexamination Certificate
active
07465572
ABSTRACT:
A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or more potential epitopes for T-cells (“T-cell epitopes”) of the given species; and (c) modifying the amino acid sequence to eliminate at least one of the T-cell epitopes identified in step (b) to reduce the immunogenicity of the protein when exposed to the immune system of the given species.
REFERENCES:
patent: 5712120 (1998-01-01), Rodriguez et al.
patent: WO 9109125 (1991-06-01), None
Bruserud et al. Journal of Clinical and Laboratory Immunology 20(2):69-74, 1986.
Adair Fiona Suzanne
Carr Francis Joseph
Carter Graham
Hamilton Anita Anne
Blanchard David J.
Merck Patent GmbH
Olson & Cepuritis, Ltd.
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