De-immunized streptokinase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C424S094100, C435S069100, C435S183000, C530S350000

Reexamination Certificate

active

07465572

ABSTRACT:
A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or more potential epitopes for T-cells (“T-cell epitopes”) of the given species; and (c) modifying the amino acid sequence to eliminate at least one of the T-cell epitopes identified in step (b) to reduce the immunogenicity of the protein when exposed to the immune system of the given species.

REFERENCES:
patent: 5712120 (1998-01-01), Rodriguez et al.
patent: WO 9109125 (1991-06-01), None
Bruserud et al. Journal of Clinical and Laboratory Immunology 20(2):69-74, 1986.

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