De-esterification process for cephalosporins

Details De-esterification process for cephalosporins De-esterification process for cephalosporins

1977-02-25

1978-05-23

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, 544 21, 544 19, C07D50120, C07D50104

Patent

active

040912140

ABSTRACT:
p-Nitrobenzyl esters of cephalosporins are reductively cleaved with zinc and .alpha.-hydroxycarboxylic acids, e.g., the p-nitrobenzyl ester of the cephalosporin antibiotic, cephalexin, is reacted in an inert solvent with zinc and mandelic acid to provide the antibiotic, cephalexin, as the free acid in yields greater than 85 percent.

REFERENCES:
patent: 3632850 (1972-01-01), Garbrecht
patent: 3781282 (1973-12-01), Garbrecht
patent: 3781282 (1973-12-01), Garbrecht
patent: 3799924 (1974-03-01), Jackson
patent: 3799924 (1974-03-01), Jackson
patent: 3828026 (1974-08-01), Woodward

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