DCC probes, primers, and kits

Details DCC probes, primers, and kits DCC probes, primers, and kits

1995-05-17

1997-02-11

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, 536 2433, 536 221, 435 6, 435 912, 435 9121, C07H 2102, C07H 2104, C12P 1934, C12Q 168

Patent

active

056022433

ABSTRACT:
A new human gene termed DCC is disclosed. Methods and kits are provided for assessing mutations of the DCC gene in human tissues and body samples. Insertion, deletion, and point mutations in DCC are observed in human tumor cells. Normal tissues express DCC while most colorectal cancers do not. Loss of wild-type DCC genes is associated with neoplastic progression and a diminished life expectancy.

REFERENCES:
patent: 5043272 (1991-08-01), Hartley
Fearon et al, "Identification of a chromosome 18q gene that is altered in colorectal cancers", Science 247:49-56.
Cho et al, "The DCC gene: Structural analysis and mutations in colorectal carcinomas", Genomics 19:525-531.
Vogelstein et al., N. Eng. J. Med. (1988), 319: 525-532.
Kern et al., JAMA (1989), 261: 3099-3103.
Baker et al., Science (1989), 244: 217-221.
Boman et al., Chem. Abstracts AN:CA109(19): 16472e.
Biochem. Biophys. Res. Commun. (1988), 155(1): 463-469.
Maxam et al., Proc. Natl Acad. Sci. USA (1977), 74(2): 560-564.
Sanger et al., Proc. Natl Acad. Sci. USA (1977), 74(2): 5463-5467.
Frati et al., "Genetics and Phenotypic Markers of Tumors," Aaronson, Plenum Press, pp. 1-20, 1984.
Friedmann et al, Science (1989), 244: 1275-1281.
Engelke et al., Proc. Natl. Acad. Sci. USA (1988), 85: 544-548.
Old et al., Principles of Gene Manipulation, 3rd Edition, Blackwell Scientific Public.
Bishop et al., "The Genetics of Colorectal Cancer", Cancer Surveys (1990), 9(4): 585-605.
Fearon et al., "Identification of a Chromosome 18q Gene that is Altered in Colorectal Cancers," Science (1990), 247: 49-56.
Kern et al., "Clinical and Pathological Associations with Allelic Loss in Colorectal Carcinoma," JAMA (1989), 261: 3099-3103.
Vogelstein et al., "Genetic Alterations During Colorectal-Tumor Development," N. Eng. J. Med. (1988), 319: 525-532.
Marlhens et al., "RFLP Identified by the Anonymous DNA Segment OL VII E10 at 18q21.3 (HGM No. D18S8)," Nucleic Acids Res. (1987), 15: 1348.
Lynch et al., "Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndromes I and II)," Cancer (1985), 56: 934-938.
O'Connell et al., "Twelve Loci Form a Continuous Linkage Map for Human Chromosome 18," Genomics (1988), 3: 367-372.
Geitvik et al., "The Kidd (JK) Blood Group Locus Assigned to Chromosome 18 by Close Linkage to a DNA-RFLP," Hum. Genet. (1987), 77: 205-209.
Stanley et al., "Construction of a New Family of High Efficiency Bacterial Expression Vectors: Identificatio of cDNA Clones Coding for Human Liver Proteins," EMBO Journal (1984), 3: 1429-1434.

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