Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-08-13
1999-11-09
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
540469, C07D51308, A61K 31425
Patent
active
059815582
ABSTRACT:
DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4, or the like; R.sup.2 represents hydrogen or COR.sup.6 ; R.sup.3 represents --CH.sub.2 OCOR.sup.7, phthalimidomethyl, or the like; and W represents oxygen or NR.sup.8 (wherein R.sup.8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).
REFERENCES:
patent: 4999196 (1991-03-01), Nakano et al.
patent: 5733924 (1998-03-01), Kanda et al.
Yamada, et al., Heterocycles, vol. 43, No. 2, (1996) 267-270.
Kanda, et al., Bioorganic & Medicinal Chemistry Letters 8, (1998) 909-912.
Arai Hitoshi
Ashizawa Tadashi
Ikeda Shun-ichi
Kanda Yutaka
Murakata Chikara
Gerstl Robert
Kyowa Hakko Kogyo Co. Ltd.
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