DC-89 derivatives as anti-tumor agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514183, 514212, 5142328, 514255, 514339, 540480, 540602, 544142, 544372, 546271, 548429, A61K 31405, C07D40312, C07D48704

Patent

active

052486923

ABSTRACT:
Novel DC-89 derivatives as shown below have an excellent anti-tumor activity, and thus are useful as anti-tumor agent ##STR1## wherein L represents chlorine or bromine; R represents ##STR2## (wherein n represents an integer of 4 to 7) or ##STR3## (wherein Y represents oxygen or N--M).

REFERENCES:
patent: 4169888 (1979-10-01), Hanka et al.
patent: 4912227 (1990-03-01), Kelly et al.
Japan J. Cancer Research 80, 686-689, 1989.
Yasuzawa et al., "Chem. and Pharm. Bull.", vol. 36, No. 9 (1988) 3728:31.

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