DC-89 derivatives

Details DC-89 derivatives DC-89 derivatives

1992-06-25

1993-11-02

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514218, 5142328, 514316, 514322, 514410, 514411, 540602, 544142, 544373, 546187, 546199, 548421, 548433, A61K 31495, A61K 31445, C07D40300, C07D48702

Patent

active

052583830

ABSTRACT:
DC-89 derivatives represented by the formula: ##STR1## wherein X represents hydrogen or CO.sub.2 CH.sub.3 ; and ##STR2## wherein Z represents Cl or Br; R represents hydrogen, CONR.sup.1 R.sup.2 (in which R.sup.1 and R.sup.2 independently represent hydrogen, a straight-chain or branched alkyl group having 1 to 4 carbon atoms or phenyl) or ##STR3## (in which n represents an integer of 0 to 4; R.sup.3 represents CH.sub.2, ##STR4## oxygen, N--CH.sub.3, or N--CH.sub.2 CONR.sup.1 R.sup.2 in which R.sup.1 and R.sup.2 have the same significances as defined above); and W represents hydrogen or ##STR5## (in which W.sup.1 and W.sup.2 independently represent hydrogen or OR.sup.2 in which R.sup.4 represents a straight-chain or branched alkyl group having 1 to 4 carbon atoms or a straight-chain or branched alkenyl group having 2 to 4 carbon atoms, and pharmaceutically acceptable salts thereof have an excellent anti-tumor and antibacterial activity and are expected to be useful as anti-tumor compositions and antibacterial compositions.

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