Db, the receptor for leptin, nucleic acids encoding the...

Details Db, the receptor for leptin, nucleic acids encoding the... Db, the receptor for leptin, nucleic acids encoding the...

2006-04-24

2009-11-17

Rao, Manjunath N (Department: 1647)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C435S006120

Reexamination Certificate

active

07619079

ABSTRACT:
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.

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