Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-03-16
2009-11-03
Rao, Manjunath N (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S362000, C530S326000, C530S327000, C530S402000, C530S403000, C514S002600, C514S006900, C514S012200, C514S013800, C514S014800
Reexamination Certificate
active
07612171
ABSTRACT:
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
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Friedman Jeffrey M.
Lee Gwo-Hwa
Proenca Ricardo
Rao Manjunath N
Shafer Shulamith H
Steptoe & Johnson LLP
The Rockefeller University
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