DB, the receptor for leptin

Details DB, the receptor for leptin DB, the receptor for leptin

2006-08-01

2006-08-01

O'Hara, Eileen B. (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C514S012200, C536S023500

Reexamination Certificate

active

07084252

ABSTRACT:
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.

REFERENCES:
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5359046 (1994-10-01), Capon et al.
patent: 5643748 (1997-07-01), Snodgrass et al.
patent: 6506877 (2003-01-01), Tartaglia et al.
patent: 90/14092 (1990-11-01), None
patent: 91/06666 (1991-05-01), None
patent: 91/09955 (1991-07-01), None
patent: 9635787 (1996-11-01), None
patent: 9725424 (1997-01-01), None
patent: 9731015 (1997-02-01), None
patent: 9712037 (1997-04-01), None
patent: 9740380 (1997-04-01), None
patent: 9741217 (1997-04-01), None
patent: 9741263 (1997-04-01), None
patent: 9742340 (1997-05-01), None
patent: 9719952 (1997-06-01), None
patent: 9725425 (1997-07-01), None
patent: 9726523 (1997-07-01), None
Vukicevic et al., 1996, PNAS USA 93:9021-9026.
Bahary et al. (1990) Proc. Natl. Acad. Sci. USA 87:8642-6.
Bahary et al.,Mammalian Genome, 4:511-515 (1993).
Bennett et al., Current Biology, 6(9): 1170-80, (1996).
Bray et al.,Am. J. Clin. Nutr., 50:891-902 (1989).
Burkhardt et al. (1994)Mol. Cell. Biol., 14:1095.
Campfield et al.,Science, 269:546 (1995).
Chen et al., Cell, 84:491-95, (1996).
Chua et al., Science, 271: 994-6, (1996).
Church et al,Nature Genetics, 6:98 (1994).
Cioffi et al., Nature Medicine, 2(5): 585-89, (1996).
Coleman,Diabetologia, 9:294-298 (1973).
Coleman et al.,Diabetologia, 14:141-148 (1978).
Considineet al.,J. Clin. Invest., 95:2986 (1995).
Dalton et al. (1993) Science 259:1736-9.
Davis et al. (1993) Science 260:1805-7.
Friedman et al.,Genomics, 11:1054-1062 (1991).
Fukunaga, et al.,EMBO, 10:2855 (1991).
Halaas et al.,Science, 269:543 (1995).
Hamilton et al.,Nature Med., 1:953 (1995).
Kishimoto et al. (1994) Cell 76:253-62.
Leiter,Endocrinology, 124:912-922 (1989).
Iida et al., Biochem Biophs Res Comm, 224:597-604, (1996).
Lonnqvist et al.,Nature Med., 1:950 (1995).
Maffei et al.,Nature Med., 1:1155 (1995).
Milatovich et al.,Somatic Cell Mol. Gen., 20:75 (1994).
Modl et al.,Cytogenetics Cell Genetics, 67:232 (1995).
Moll et al.,Am. J. Hum. Genet., 49:1243-1255 (1991).
Morgan et al.,Nucl. Acids Res., 20:5173 (1992).
Murakami et al.,Proc. Natl. Acad. Sci. USA, 88:11349 (1991).
Pellymounter et al.,Science, 269:540, (1995).
Riley et al.,Nucl. Acids Res., 18:2887 (1990).
Sanchez et al.,J. Exp. Med., 178:1049 (1993).
Stephens et al.,Nature, 377:530 (1995).
Tartaglia et al. (1995) Cell 83:1263-71.
Truett et al.,Proc. Natl. Acad. Sci. USA, 88:7806-7809 (1991).
Turton et al.,Nature, 379:69 (1996).
Zhang et al.,Nature, 372:425 (1994).

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