Daz: a gene associated with azoospermia

Details Daz: a gene associated with azoospermia Daz: a gene associated with azoospermia

1996-07-31

1999-02-16

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 536 231, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

058719202

ABSTRACT:
Novel gene present in interval 6E of the distal portion of the long arm of the human Y chromosome, whose alteration is associated with reduced sperm count. Methods of diagnosis and treatment utilizing said gene, and antibodies that bind to the protein encoded by said gene.

REFERENCES:
Glaser et al. Chromosome Research 5: 23-30, 1997.
Yen et al. Am J. of Human Genetics 57; A876, 1995.
Reijo et al. Nature Genetics 10:383-393, 1995.
Foote et al. Science 258: 60-66, 1992.
Ma, Kun et al., "A Y Chromosome Gene Family with RNA-Binding Protein Homology: Candidates for the Azoospermia Factor AZF Controlling Human Spermatogenesis", Cell 75:1287-1295 (1993).
Foote, Simon et al., "The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region", Science 258:60-66 (1992).
Vollrath, Douglas et al., "The Human Y Chromosome: A 43-Interval Map Based on Naturally Occurring Deletions", Science 258:52-59 (1992).

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