Daunorubicin derivatives, their preparation and their use

Details Daunorubicin derivatives, their preparation and their use Daunorubicin derivatives, their preparation and their use

1977-06-27

1978-12-26

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 4, 536 17, A61K 3170, C07H 1524

Patent

active

041316495

ABSTRACT:
Daunorubicin (also known as daunomycin) derivatives of the formula ##STR1## wherein X is ##STR2## and R is --COCF.sub.3 or H which are prepared by hydrogenating 9-desacetyl-9-keto-N-trifluoroacetyldaunorubicin, an unexpectedly stable key-intermediate which is itself a new compound, are useful in treating certain mammalian tumors.

REFERENCES:
patent: 4020270 (1977-04-01), Arcamone et al.
patent: 4025623 (1977-05-01), Arcamone et al.

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