Daunorubicin derivatives

Details Daunorubicin derivatives Daunorubicin derivatives

1977-11-09

1980-09-30

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 17A, A61K 3170, C07G 1100

Patent

active

042255899

ABSTRACT:
Daunorubicin derivatives of the formula: ##STR1## wherein R.sub.1 represents a group of the formula: ##STR2## in which (i) X.sub.1 and X.sub.2 both represent oxygen or both represent sulphur and the symbols R.sub.3 each represent alkyl of 1 through 4 carbon atoms, phenyl or phenyl substituted in the para-position by methyl, methoxy or methylthio, or together form an alkylene radical of 2 through 4 carbon atoms, or (ii) one of X.sub.1 and X.sub.2 represents oxygen and the other represents sulphur and the symbols R.sub.3 together form an alkylene radical of 2 through 4 carbon atoms, and R.sub.4 represents hydrogen, alkyl of 1 through 4 carbon atoms or phenyl, and R.sub.2 represents hydrogen or trifluoroacetyl, are new compounds possessing anti-tumour properties.

REFERENCES:
patent: 4031211 (1977-06-01), Patelli et al.
American Druggist, May 19, 1969, (Pharm. & Med. Science, pp. 33-34). _
Journ. Med. Chem., 1974, vol. 17, No. 3, pp. 335-337. _
Experientia 26, 4, pp. 389-390 (1970). _
Merck Index, 9th Edition, 1976, No. 3428. _

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