Daunomycins, process for their uses and intermediates

Details Daunomycins, process for their uses and intermediates Daunomycins, process for their uses and intermediates

1975-03-19

1977-08-02

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 4, 536 17, 536 18, 536115, 536122, A61K 3171, C07H 1100

Patent

active

040396630

ABSTRACT:
The known antibiotic daunomycin, and the novel compounds daunomycin-.beta.-anomer and 4'-epidaunomycin (both .alpha.- and .beta.-anomers) are prepared by condensing daunomycinone with reactive novel intermediates which are 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-.alpha.-L- lyxo (or arabino) hexopyranoses.

REFERENCES:
patent: 2949449 (1960-08-01), Hoffer
patent: 3356674 (1967-12-01), Ikeda et al.
patent: 3427300 (1969-02-01), Sarett et al.
patent: 3501456 (1970-03-01), Shen et al.
patent: 3524844 (1970-08-01), Keller-Juslen et al.
patent: 3686163 (1972-08-01), Arcamone et al.
patent: 3803124 (1974-04-01), Arcamone et al.

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