Daunomycin derivative with reduced cytotoxicity toward normal ce

Details Daunomycin derivative with reduced cytotoxicity toward normal ce Daunomycin derivative with reduced cytotoxicity toward normal ce

1992-07-31

1995-05-09

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 64, A61K 3170, C07H 1524

Patent

active

054139929

ABSTRACT:
Chemotherapeutic agents that exhibit cytotoxicity similar to that of daunomycin against cancer cells, but exhibit lessened cytotoxicity against normal, non-transformed cells are disclosed, as are compositions, processes for making and using the same. A contemplated chemotherapeutic agent is a daunomycin derivative whose structure corresponds to structural Formula I, wherein Ar is phenyl, 1-naphthyl or 2-naphthyl ##STR1##

REFERENCES:
patent: 4973674 (1990-11-01), Brasca et al.
patent: 4973675 (1990-11-01), Israel et al.
Johnson et al, Cancer Treatment Reviews (1975), 2, 1-31 "The Clinical impact of screening and other experimental donor studies".

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