Daunomycin analogues, their preparation and use

Details Daunomycin analogues, their preparation and use Daunomycin analogues, their preparation and use

1975-05-22

1977-09-06

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 4, 536 17, 536 18, A61K 3171, C07H 1100

Patent

active

040468780

ABSTRACT:
Daunomycin analogues of the formula: ##STR1## wherein when each R.sub.1 is hydrogen, each R is hydrogen, chlorine, bromine, methyl or methoxy and when each R.sub.1 is chlorine, bromine or methyl, each R is hydrogen, are useful in treating various mammalian tumors and are prepared by reacting a daunomycinone derivative of the formula: ##STR2## wherein R and R.sub.1 are as defined above with 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-.alpha.-L- lyxopyranose in an inert anhydrous organic solvent in the presence of a catalyst and a hydrogen chloride acceptor.

REFERENCES:
patent: 3427300 (1969-02-01), Sarett et al.
patent: 3686163 (1972-08-01), Arcamone et al.
patent: 3803124 (1974-04-01), Arcamone et al.

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