D1- and 8R-9-fluoro-prostadienoic acid derivatives

Details D1- and 8R-9-fluoro-prostadienoic acid derivatives D1- and 8R-9-fluoro-prostadienoic acid derivatives

1975-06-26

1976-12-14

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 260256, 260448R, 2605011, 26050117, 2605012, 260514D, 424305, 424317, C07C17700

Patent

active

039975878

ABSTRACT:
d1- and 8R-9-fluoro-11,15.alpha.-dihydroxyprosta-5-cis,13-trans-dienoic acid, d1- and 8R-9-fluoro-11,15.alpha.-dihydroxy-15.beta.-methyl-prosta-5-cis,13-trans-d ienoic acid and d1- and 8R-9-fluoro-11,15.beta.-dihydroxy-15.alpha.-methylprosta-5-cis,13-trans-di enoic acid, the pharmaceutically acceptable, nontoxic lower alkyl esters and salts thereof and process for the production of such compounds. 8R-9.beta.-fluoro-11.alpha.,15.alpha.-dihydroxyprosta-5-cis,13-trans-dieno ic acid is a representative compound of the class. These compounds possess prostaglandin-like activities and thus are useful in the treatment of mammals where prostaglandins are indicated. They are particularly useful as luteolytic agents in female mammals and as bronchodilators.

REFERENCES:
sharts et al., Organic Reactions 21, p. 158, (1974).

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