D-type cyclins and uses related thereto

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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Details

435 691, 435 697, 435194, C07K 1447, C12P 2102, C12N 912

Patent

active

059985828

ABSTRACT:
A novel class of cyclins, referred to as D-type cyclins, of mammalian origin, particularly human origin, DNA and RNA encoding the novel cyclins, and a method of identifying other D-type and non-D type cyclins. Also disclosed are a method of detecting an increased level of a D-type cyclin and a method of inhibiting cell division by interfering with formation of the protein kinase-D type cyclin complex essential for cell cycle start.

REFERENCES:
Motokura, T. et al. (1991) "A novel cyclin encoded by a bcl1-linked candidate gene" Nature 350:512-515, Apr. 1991.

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