Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1995-06-05
2000-05-23
Brusca, John S.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435 6, 435 911, 536 245, C12N 1500, C12N 1511, C07H 2104
Patent
active
060665017
ABSTRACT:
A novel class of cyclins, referred to as D-type cyclins, of mammalian origin, particularly human origin, DNA and RNA encoding the novel cyclins, and a method of identifying other D-type and non-D type cyclins. Also disclosed are a method of detecting an increased level of a D-type cyclin and a method of inhibiting cell division by interfering with formation of the protein kinase-D type cyclin complex essential for cell cycle start.
REFERENCES:
Shi et al "Transcatheter Delivery of c-myc Antisense Oligomers Reduces Neointimal Formation in A Porcine Model of Coronary Artery Ballon Injury", Circulation vol. 90(2): 944-951, 1994.
Branch A. "A Good Antisense Molecular is Hard to Find" TIBS vol. 23:45-50, Feb. 1998.
Agrawal S. "Antisense Oligonucleotides: Towards Clinical Trials" TIBTECH vol. 14:376-387, Oct. 1996.
Gura, T. "Antisense Has Growing Pains", Science vol. 270: 575-577, Oct. 27, 1995.
Wu Pong. Pharmaceutical Technology vol. 18: 102-114, Oct. 1994.
Stull, R. et al "Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects", Pharmaceutical Research. vol. 12(4): 465-483, 1995.
Bennet, F. "Antisense Research", Science vol. 271:434, Jan. 26, 1996.
Westermann, B. et al "Inhibition of Expression of SV40 virus large T-antigen byAntisense Oligonucleotides", Biomed. Biochim. Acta. vol. 48: 85-93, 1989.
Milligan, J. "Current Concepts in Antisense Drug Design", J. Medicinal Chemistry. vol. 36(14): 1923-1937, Jul. 9, 1993.
Miller, N. et al "Gene Transfer and Antisense Nucleic Acid Techniques", Parisitology Today. vol. 10(3): 92-97, 1994.
Rojanasakul, Y. "Antisense Oligonucletide Therapeutics: Drug Delivery and Targeting", Advanced Drug Delivery Reviews. vol. 18: 115-131, 1996.
Weiss, R. "Upping the Antisense Ante", Science News, vol. 139: 108-109, 1991.
Stein, C. et al. "Antisense Oligonucleotides as Therapeutic Agents--Is the Bullet Really Magical?" Science vol. 261: 1004-1012, Aug. 20, 1993.
Brusca John S.
Cold Spring Harbor Laboratory
McGarry Sean
Varma Anita
Vincent Matthew P.
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