D-tagatose as anti-hyperglycemic agent

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 23, 514866, 514884, A61K 3170

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active

053568796

ABSTRACT:
This invention discloses the usefulness of D-tagatose as a treatment for hyperglycemia, diabetes mellitus, and the inhibition of formation of advanced glycosylation end-products associated with the aging process.
This invention discloses edible formulations and pharmaceutical compositions containing D-tagatose and the effect of consumption of such formulations on blood level of glucose. D-Tagatose was found to be an anti-hyperglycemic agent. In addition, consumption of D-tagatose in sweetened formulations to inhibit formation of advanced glycosylation end-products in mammals is disclosed. The combination of the anti-hyperglycemic effect and the inhibition of formation of glycosylated proteins and nucleic acids make D-tagatose an ideal agent for alleviating the complications resulting from hyperglycemia, including acceleration of the aging process.

REFERENCES:
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patent: 4983582 (1991-01-01), Murata et al.
patent: 5166193 (1992-11-01), Levin et al.
N. B. Ruderman, A. McCall, "Disorders of Carbohydrate Metabolism", pp. 778-797, Medicine, Eds. R. W. Wilkins, N. G. Levinsky, Little Brown Co. Boston 1983.
A. Cerami et al., Glucose and Aging, Scientific American vol. 256, pp. 90-96, 1987.
A. Cerami, J. Am. Geriatr. Soc., vol. 33, pp. 626-645, 1985.
H. F. Bunn et al. "Reaction of Monosaccharides with Proteins: Possible Evolutionary Significance", Science, vol. 213, pp. 222-224, 10 Jul. 1981.
G. J. Wolff et al. Chemie Zeitung vol. 103, No. 6, pp. 232-233, 1979.

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