d.sub.4 T polymorphic Form 1 process

Details d.sub.4 T polymorphic Form 1 process d.sub.4 T polymorphic Form 1 process

1995-06-05

1997-03-04

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2714, C07H 1906

Patent

active

056080484

ABSTRACT:
The present invention concerns a novel process using controlled cooling for obtaining d.sub.4 T polymorphic Form I from a mixture containing one or more of polymorphic Forms I, II and III. Compound d.sub.4 T has been approved for use in the treatment of AIDS.

REFERENCES:
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patent: 4978655 (1990-12-01), Lin et al.
Udupa, N, "Effect of Crystallinity and Solubilizing Agents on Absorption and Excretion Patterns of Ibuprofen," The Eastern Pharmacist, Scientific Section, vol. XXX, No. 350, pp. 137-140 (Feb. 1987).
Harte, W. E., et al., Biochemical and Biophysical Research Comm., 175(1), pp. 298-304 (1991).
Gurskaya, G. V., et al., Molekulyarnaya Biologiya, 25(2), pp. 483-491 (Mar.-Apr., 1991) (Russian) translated 1991 in Plenum Publishing Corp., pp. 401-408.

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