D ring intermediates for the synthesis of camptothecin and campt

Details D ring intermediates for the synthesis of camptothecin and campt D ring intermediates for the synthesis of camptothecin and campt

1993-03-23

1993-11-23

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546302, C07D21364

Patent

active

052645797

ABSTRACT:
Processes for making compounds of Formulae XIV, XV, and XVII ##STR1## wherein R.sub.6 is lower alkyl, R.sub.7 is lower alkyl, R is lower alkyl, Y is H, F or Cl, R.sub.8 is a compound of Formula ##STR2## wherein n is 1, 2, or 3, R.sub.11 is C.sub.1 -C.sub.4 alkyl and R.sub.12 is the same as R.sub.11, or R.sub.11 and R.sub.12 together form cyclopentane or cyclohexane, and R.sub.13 is:

REFERENCES:
patent: 3109018 (1963-10-01), Hanover
patent: 3607651 (1971-09-01), Moroz
patent: 3943181 (1976-03-01), Fleischer et al.
patent: 4418225 (1983-11-01), House
patent: 4578381 (1986-03-01), Uchida et al.
patent: 4720558 (1988-01-01), Kaulen
patent: 4894456 (1990-01-01), Wall et al.
patent: 4916074 (1990-04-01), Yoshida et al.
patent: 4962031 (1990-10-01), Yoshida et al.
patent: 4963492 (1990-10-01), Keller et al.
patent: 4996158 (1991-02-01), Oda et al.
patent: 5021345 (1991-06-01), Urban et al.
patent: 5032523 (1991-07-01), Amano et al.
patent: 5057427 (1991-10-01), Wald et al.
R. Lawrence, "The Resolution and Use of Chiral Auxiliaries in Asymmetric Synthesis," Dissertation presented to the faculty of the University of Texas at Austin (UMI) Ann Arbor, Mich.) Dec., 1988.
R. Benkeser et al., J. Am. Chem. Soc. 85, 3984-3989 (1963).
G. Langrand et al., Tetrahedron Letters 26, No. 15, 1857-1860 (1985).
W. Oppolzer et al., Helvetica Chimica Acta 63, Fasc. 7, 2015-2018 (1980).
J. Whitesell, Acc. Chem. Res. 18, 280-284 (1985).
J. Whitesell and R. Lawrence, Chimia 40, No. 9, 318-322 (1986).
D. Wilhelm et al., J. Am. Chem. Soc. 106, No. 2, 361-367 (1984).
Lyle et al., 23d International Congress of Pure and Applied Chemistry (Boston, Mass. 1971), p. 67.
Portlock et al., Org. Chem. 38, No. 13, 2351-2355 (1973).
Plattner et al., J. Amer. Chem. Soc. 94, No. 24, 8613-8615 (1972).
Sugasawa et al., Chem. Pharm. Bull. 22, No. 4, 763-770 (1974).
"Heterocyclic Compounds: Pyridine and Its Derivatives", vol. 14, Supplement Part 3 (John Wiley & Sons, Inc., Ed. Abramovitch), pp. 745-753 (1974).
Bristol et al., Journal of Medicinal Chemistry 18, No. 5, 535 (1975).
Cai et al., The Alkaloids XXI, 101 (Academic Press 1983).
Comins et al., J. Org. Chem. 55, No. 1, 69 (1990).
Comins et al., J. Org. Chem. 54, No. 15, 3730 (1989).
Comins et al., Tetrahedron Letters 29, No. 7, 773 (1988).
Comins et al., J. Org. Chem. 49, No. 6, 1078 (1984).
Comins, PhD Thesis, University of New Hampshire, Durham, N.H., pp. 25-29 (1977).
Doyle et al., J. Am. Chem. Soc. 94, No. 10, 3659 (1972).
R. Grigg et al., Tetrahedron 46, No. 11, 4003 (1990).
Larock, "Comprehensive Organic Transformations: A Guide to Functional Group Preparations," (VCH Publishers, Inc., New York, N.Y.) pp. 467-468 (1989).
Larock, "Comprehensive Organic Transformations: A Guide to Functional Group Preparations," (VCH Publishers, Inc., New York, N.Y.) pp. 501-504 (1989).
Lyle et al., J. Org. Chem. 38, No. 19, 3268 (1973).
Lyle et al., J. Org. Chem. 37, No. 24, 3967 (1972).
March, "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure," Third Edition, (John Wiley & Sons, Inc.) pp. 510-511 (1985).
"Natural Products Chemistry," vol. 2 (Academic Press, Inc., Ed. K. Nakanishi et al.), pp. 358-361 (1981).
"Natural Products Chemistry," vol. 3 (Academic Press, Inc., Ed. K. Nakanishi et al.), pp. 573-574 (1982).
Schmidt, Aldrichimica Acta, 14, No. 2, 31 (1981).

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