D-propranolol as a selective adenosine antagonist

Details D-propranolol as a selective adenosine antagonist D-propranolol as a selective adenosine antagonist

1989-06-30

1992-05-26

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514546, 560106, 560107, 560129, 560252, 560231, A61K 3124, A61K 3122, C07C 6976, C07C 6902

Patent

active

051168677

ABSTRACT:
Chemicals are disclosed which are useful for inhibiting the actions of adenosine in mammals, comprising: L-propranolol, or D-propranolol, or alprenolol and derivatives thereof for parenteral or topical administration are disclosed for purposes of achieving desired circulating concentrations in the range of 10 nanogram to 10 milligrams per kilogram.
D-Propranolol is of special interest because it is relatively inactive as a .beta.-adrenergic blocking agent. Specific uses of D-propranolol include the treatment of asthma, chronic obstructive pulmonary disease, A-V node conduction disturbances; apnea of preterm infants, pulmonary hypertension, headaches, migraine, and in attention-deficit disorder. D-Propranolol might also be used as a substitute for xanthines in beverages to produce a feeling of well being, awakeness, awareness and increased performance.

REFERENCES:
patent: 3534085 (1970-10-01), Narayanan et al.
Grimes et al. Invest. Ophthalmol. 1972, 11(4) 231-5 Chemical Abstracts, vol. 77, 1972, Abstract 43303h.
Nilsson et al. Acta Endocrinol. 1980 94(1) 38-41 Chemical Abstracts vol. 93, 1980 Abs. 88913d.
Chasin et al., J. Biol. Chem. 246(9) pp. 3037-3041.
Farthing, et al. J. Antimicrobial Chemother. 1987 20(4) 519-22 Chemical Abstracts vol. 107, 1987, Abstract 232966a.

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