Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-06-07
2005-06-07
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S422000, C540S455000, C548S524000
Reexamination Certificate
active
06903129
ABSTRACT:
The invention relates to compounds of formulaswhereinR1and R2are independently from each other lower alkoxy, lower alkenyloxy, benzyloxy, hydroxy, —OCH(CH3)OC(O)-lower alkyl or —OCH2C(O)N(R3)(R4), with the proviso that only one of R1or R2may be hydroxy;R3and R4are independently from each other and signify hydrogen, lower alkyl, lower alkenyl or cycloalkyl; orR1and R2form together with the carbon atom, to which they are attached the linking group X, whereinX is —O(CH2)nCH═CH(CH2)nO— or —O(CH2)mO—;n is 1, 2 or 3; andm is 4-8, ora pharmaceutically acceptable salt of said compound.Compounds of the present invention can be used for the treatment of diseases where Serum Amyloid P Component depletion has a beneficial effect, in particular in the treatment or prevention of central and systemic amyloidosis.
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Huwyler Joerg
Jakob-Roetne Roland
Poli Sonia Maria
Hoffman-La Roche Inc.
Johnston George W.
Kifle Bruck
Rocha-Tramaloni Patricia S.
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