D-Phenylalanyl-L-prolyl-L-arginine aldehyde sulfate and process

Details D-Phenylalanyl-L-prolyl-L-arginine aldehyde sulfate and process D-Phenylalanyl-L-prolyl-L-arginine aldehyde sulfate and process

1982-01-05

1983-08-16

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

043990657

ABSTRACT:
The invention relates to D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate, highly stable in aqueous solution, and to a process for preparing it from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or N.sup.G -carboxy derivative containing an acid-sensitive protecting group at its amino terminal, wherein the acid sensitive amino terminal protecting group or optionally the N.sup.G -carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts and the resulting free tripeptide aldehyde sulfate is isolated. The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anticoagulant activity.

REFERENCES:
patent: 3826793 (1974-07-01), Blomback et al.
patent: 4316889 (1982-02-01), Bajusz et al.

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