D-myo-inositol 1,4,5-trisphosphate analogues

Details D-myo-inositol 1,4,5-trisphosphate analogues D-myo-inositol 1,4,5-trisphosphate analogues

1994-01-13

1995-02-28

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

C07F 9117

Patent

active

053939123

ABSTRACT:
Two types of structural analogues of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P.sub.4 ] are prepared by a chemo-enzymatic route. These 6-O-substituted analogues retain the biological activity of Ins(1,4,5)P.sub.3 and are able to elicit Ca.sup.2+ release from porcine brain microsomes. Moreover, these analogues allow the preparation of Ins(1,4,5)P.sub.3 -based immunogens and affinity matrix which are successfully applied to the preparation and purification of antibodies against Ins(1,4,5)P.sub.3. These antibodies display discriminative affinity toward Ins(1,4,5)P.sub.3, and provide a useful tool to study intracellular Ca.sup.2+ mobilization.

REFERENCES:
patent: 4873355 (1989-10-01), Hobbs et al.
patent: 5210263 (1993-05-01), Kozikowski et al.
patent: 5260472 (1993-11-01), Chen
patent: 5292913 (1994-03-01), Ozaki et al.

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