Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1998-01-21
1999-12-28
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514812, A01N 3302, A61K 31135
Patent
active
060082585
ABSTRACT:
The present invention relates to a method of treating pain in a subject having a NMDA recptor which includes administering d-methadone, d-methadol, d-alpha-acetylmethadol, l-alpha-acetylmethadol, d-alpha-normethadol, l-alpha-normethadol, pharmaceutically acceptable salts thereof, or mixtures thereof, to the subject under conditions effective for the substance to bind to the NMDA receptor of the subject. The present invention further relates to a method of treating tolerance and physical dependence in a subject and a method of binding to a NMDA receptor.
REFERENCES:
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patent: 5321012 (1994-06-01), Mayer et al.
patent: 5352683 (1994-10-01), Mayer et al.
patent: 5502058 (1996-03-01), Mayer et al.
patent: 5556838 (1996-09-01), Mayer et al.
patent: 5654281 (1997-08-01), Mayer et al.
Olsen et al.: Clinical Effects and Pharmacokinetics of Racemic Methdone and Its Optical Isomers, 1977, 147-57, see entire abstract.
Kristensen et al: Stereoselective Pharmacokinetics of Methadone in Chronic Pain Patients, 1996, 221-227, see entire abstract.
Choi et al: Opioids and Non-Opioid Enantiomers Selectively Attenuate NMDA Neurotoxicity on Cortical Neurons, 27-35, see entire abstract.
Cornell Research Foundation Inc.
Krass Frederick
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